منابع مشابه
Neutrophil toxicity of amphotericin B.
The toxicity of amphotericin B (AmB) for neutrophils and the protective effect of serum cholesterol were investigated. Neutrophils were exposed in vitro to varying concentrations of AmB. As judged by trypan blue exclusion, neutrophil viability decreased by 40% (P < 0.001) within 30 min of incubation in sterol-free buffer containing 5 mug of AmB per ml. In the presence of 4 mg of cholesterol per...
متن کاملPentoxifylline in amphotericin B toxicity rat model.
The mechanism of acute nephrotoxicity following the administration of amphotericin B (AmpB) remains unclear despite a number of studies describing hypermagnesuria, hyperkaluria, and hemodynamic changes. The present experiments attempted to elucidate the mechanism by using a novel hemorheologic probe, pentoxifylline (PTX). Acute studies were performed with rats given single intravenous doses of ...
متن کاملAmphotericin B: side effects and toxicity.
Amphotericin B (AmB) is a crucial agent in the management of serious systemic fungal infections. In spite of its proven track record, its well-known side effects and toxicity will sometimes require discontinuation of therapy despite a life-threatening systemic fungal infection. The mechanism of action of AmB is based on the binding of the AmB molecule to the fungal cell membrane ergosterol, pro...
متن کاملStimulation of human and canine neutrophil metabolism by amphotericin B.
The effect of an antifungal agent, amphotericin B, on human and canine neutrophil metabolism was studied. Commercial preparations of amphotericin B in concentrations ranging from 5 to 100 micrograms/ml stimulated neutrophil chemiluminescence in the presence of 10(-8) M luminol. This response was blocked by 2-deoxyglucose, a metabolic inhibitor, and by the absence of extracellular calcium ions. ...
متن کاملInfluence of diet on experimental toxicity of amphotericin B deoxycholate.
The effects of pre- and postprandial levels of lipids in serum on the experimental in vivo and in vitro toxicities of amphotericin B deoxycholate (AmB-d) were studied. Normal OF1 mice were tested at baseline, after normal feeding, after 3 h of fasting, or after a sequence of feeding and fasting and vice versa. The 50% lethal dose (LD50) of AmB-d was significantly higher in fed mice than in mice...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 1977
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.12.2.226